There are no comment yet.
Edge Weighted
Definition
Edge weight EW(u,v) use the following commonly used measures for evaluating the relationship between
two proteins, whose nodes are connected by an edge in a PPI network and defined as:
where GE is GO functional similarity, PCC is co-expression levels
among genes and NTE is the number of times that a PPI pair involved in PPI triangles.
EW(u,v) = NTE(u,v) * PCC(u,v) * GE(u,v)
Software
References
- WANG, Y., SUN, H., DU, W., BLANZIERI, E., VIERO, G., XU, Y. & LIANG, Y. 2014. Identification of Essential Proteins Based on Ranking Edge-Weights in Protein-Protein Interaction Networks. PLoS ONE, 9, e108716.