Edge weight EW(u,v) use the following commonly used measures for evaluating the relationship between two proteins, whose nodes are connected by an edge in a PPI network and defined as:
where GE is GO functional similarity, PCC is co-expression levels among genes and NTE is the number of times that a PPI pair involved in PPI triangles.
EW(u,v) = NTE(u,v) * PCC(u,v) * GE(u,v)
- WANG, Y., SUN, H., DU, W., BLANZIERI, E., VIERO, G., XU, Y. & LIANG, Y. 2014. Identification of Essential Proteins Based on Ranking Edge-Weights in Protein-Protein Interaction Networks. PLoS ONE, 9, e108716.
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