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ATC - Annotation Transcriptional Centrality
Definition
Annotation transcriptional centrality (ATC) computed by integrating gene expression profiles from microarray experiments with biological knowledge extracted from public genomic databases. ATC computation algorithm delimits representative functional domains in the co-expression network and then relies on this information to find key nodes that modulate propagation of functional influences within the network. Demonstrated that ATC ability to predict important genes in several experimental models and provide improved biological relevance over conventional topological network centrality measures.
Software
- FunNet
http://www.funnet.info
References
- PRIFTI, E., ZUCKER, J. D., CLEMENT, K. & HENEGAR, C. 2010. Interactional and functional centrality in transcriptional co-expression networks. Bioinformatics, 26, 3083-9.