Based on the definitions of Ecc, the Gene Ontology similarity (GO sim) and PCC, a new centrality method named TEO is proposed. The essential nature of a protein is determined by the probability that the protein co-cluster, co-expresses, and shares similar functions with its neighbors.


  • Zhang, W., Xu, J., Li, Y. and Zou, X., 2016. Detecting Essential Proteins Based on Network Topology, Gene Expression Data and Gene Ontology Information. IEEE/ACM transactions on computational biology and bioinformatics. DOI: 10.1109/TCBB.2016.2615931 Publisher web site Endnote RIS file